System of investigation of the toxicological safety of Cuban bioproducts
Authors:
• Osmany Marrero Chang
• Edisleidy Águila Jiménez
• Alfredo Irenaldo Meneses Marcel
• Zoe Alicia Castanedo Hernandez
• Mirieisy Seijo Wals
Summary
Currently the negative impacts, to humans and the environment, due to anthropogenic activities and interventions are increasingly serious and many of them are irreversible if they are not diagnosed and corrected in the initial stages of their use. It is a growing concern in the scientific community to predict or estimate the impacts of any new product when interacting with man and the environment. Preclinical or evaluative toxicology plays a fundamental role in this problem. Related to the above, the Center for Chemical Bioactives has been carrying out, for several years, the development of toxicological evaluations and the determination of risk in mammals as part of the research and development of national candidates for bioproducts for use in agriculture, bioremediation and other uses. A battery of tests with laboratory mammals is implemented to measure lethal and sublethal effects at high doses. The methodologies used are those proposed by the EPA, the United States and the OECD. The development of the evaluations has made it possible to have a tool for determining the safety in humans and the environment of bioproducts and the provision of technical scientific services in high national and international demand.
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